UBC12 Background Information Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). UBC12, also known as UBE2M (ubiquitin-conjugating enzyme E2M), hUbc12 or UBC-RS2, is a 183 amino acid member of the E2 ubiquitin-conjugating enzyme family. UBC12 is linked with NEDD8 (neural precursor cell expressed, developmentally down-regulated 8), a ubiquitin-like protein. Via this interaction, UBC12 facilitates the attachment of NEDD8 to proteins targeted for degradation. Due to its ability to control the conjugation of NEDD8 to cellular proteins, UBC12 is thought to play a role in cell proliferation events.
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UBC12 (L-34)
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UBC12 (L-34): sc-100608. Western blot analysis of UBC12 expression in non-transfected: sc-117752 (A) and human UBC12 transfected: sc-116642 (B) 293T whole cell lysates.
UBC12 (L-34): sc-100608. Western blot analysis of UBC12 expression in Ramos whole cell lysate.
UBC12 (L-34): sc-100608. Immunofluorescence staining of paraformaldehyde-fixed HeLa cells showing nuclear localization.
UBC12 (L-34): sc-100608. Western blot analysis of UBC12 expression in Jurkat whole cell lysate.
