ICT1 Background Information Stem cell differentiation in the adult colon leads to 3 distinct cell types that make up the tissue of the lower intestine. Neoplastic transformation can deviate a stem cell, or its early descendants, along the maturation pathway that leads to these 3 cell types. This neoplastic-induced deviation is marked by a change in expression of several mRNAs. ICT1, also known as DS-1, is a member of the prokaryotic/mitochondrial release factor family whose expression is downregulated over 4 fold upon colon stem cell differentiation. This downregulation of ICT1 could lead to its use as a marker for detection of colon carcinomas.
ICT1 (2A8)
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ICT1 (2A8): sc-100658. Western blot analysis of ICT1 expression in HeLa whole cell lysate.
