DAZ Background Information Spermatogenesis is the process by which male spermatogonia develop into mature spermatozoa. DAZ (deleted in azoospermia) are RNA-binding proteins that play an essential role in spermatogenesis. DAZ proteins influence the first stages of spermatogenesis and the maintenance of germ cell populations. DAZ proteins (DAZ1, DAZ2, DAZ3, DAZ4 and DAZ5) are encoded by separate genes on chromosome Y, each of which contain an AZFc domain in their codinga region. DAZ proteins are localized to the nucleus of spermatogonia, but relocate to the cytoplasm during meiosis. DAZ proteins contain an RRM (RNA recognition motif) domain that may regulate mRNA translation by binding to the 3’UTR. Deletions in the genes encoding DAZ proteins may cause azoospermia or oligospermia which can lead to male infertility.
DAZ (Z6Q)
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DAZ (Z6Q): sc-100705. Western blot analysis of DAZ expression in Daoy whole cell lysate.
DAZ (Z6Q): sc-100705. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human testis tissue showing cytoplasmic localization.
