GTPBP9 Background Information GTP-binding protein 9 (GTPBP9), also known as Obg-like ATPase 1 (OLA1), is a 396 amino acid protein that belongs to the Obg-related GTPase family under the translation factors (TRAFAC) class. Originally thought to only have GTPase activity, Obg-related GTPase family members have been shown to also have ATPase activity. In Homo sapians, GTPBP9 exhibits a preference for binding ATP over GTP, with GTP binding occuring only at high nucleotide concentration. One cause for ATP affinity and GTP discrimination is thought to be a substitution of glutamine for a hydrophobic amino acid in Obg-related family members; this is the same substitution that inactivates Ras-like GTPases. GTPBP9 contains a C-terminal TGS domain that binds to ligands and an N-terminal G domain which binds nucleotides. GTPBP9 is expressed as three isoforms produced by alternative splicing.
GTPBP9 (T-17)
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GTPBP9 (T-17): sc-101969. Western blot analysis of GTPBP9 expression in non-transfected 293: sc-110760 (A), human GTPBP9 transfected 293: sc-113027 (B) and Hep G2 (C) whole cell lysates.
GTPBP9 (T-17): sc-101969. Immunoperoxidase staining of formalin fixed, paraffin-embedded human muscle tissue showing cytoplasmic staining.
GTPBP9 (T-17): sc-101969. Western blot analysis of GTPBP9 expression in Hep G2 whole cell lysate.
GTPBP9 (T-17): sc-101969. Western blot analysis of GTPBP9 expression in non-transfected 293T: sc-117752 (A), mouse GTPBP9 transfected 293T: sc-126929 (B) and Hep G2 (C) whole cell lysates.
