KBTBD10 Background Information KBTBD10 (Kelch repeat and BTB domain-containing protein 10), also known as Kel-like protein 23, sarcosin or Kelch-related protein 1, is a 606 amino acid cytoplasmic protein found in sarcomeric muscle. KBTBD10 plays an important role in the protein ubiquitination pathway by acting as the substrate-specific adaptor of an E3 ubiquitin-protein ligase complex. KBTBD10 forms this complex with CUL-3 and Rbx1, and also interacts with N-RAP. Although predominantly cytoplasmic, KBTBD10 can co-localize with Actin at the ruffle-like membrane structures located at the tips of pseudopodia, indicating a role in pseudopod elongation in transformed cells. KBTBD10 contains five Kelch repeats and one BTB (POZ) domain. Due to alternative splicing events, KBTBD10 exists as two isoforms.
KBTBD10 (D-25)
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KBTBD10 (D-25): sc-101989. Western blot analysis of BTBD10 expression in human fetal muscle tissue extract.
