TAF6L Background Information In eukaryotic systems, the process of initiating transcription from protein-coding genes requires the presence of RNA polymerase II and a broad family of auxiliary transcription factors. TFIID is a general transcription factor that initiates preinitiation complex assembly through direct interaction with the TATA promoter element. Functioning as a multisubunit complex consisting of a small TATA-binding polypeptide and other TBP-associated factors (TAFs), TFIID mediates promoter responses to various transcriptional activators and repressors. TAF6L, also known as PAF65A, is a 622 amino acid nuclear protein that functions as part of the PCAF (p300/CBP-associated factor) histone acetylase complex. Working in conjunction with several other TAF proteins, TAF6L acetylates nucleosomal histones, a process that is required for proper transcription and differentiation. Upon DNA damage, TAF6L may be phosphorylated by ATR or ATM.
TAF6L (E-21)
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TAF6L (E-21): sc-102126. Western blot analysis of TAF6L expression in Jurkat whole cell lysate.
