epitope mapping near the N-terminus of JAGN1 of human origin
recommended for detection of JAGN1 of mouse and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
JAGN1 Background Information The gene encoding JAGN1, a 183 amino acid protein, maps to human chromosome 3. Chromosome 3 is made up of about 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.
