epitope mapping within an internal region of OGG1/2 of human origin
recommended for detection of all OGG1 splice variants of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including bovine and porcine
OGG1/2 Background Information 8-oxoguanine (8-oxoG), an oxidized form of guanine, is produced by reactive oxygen species in both DNA and nucleotide pools during normal aging. Accumulation of 8-oxoG increases the occurrence of A:T to C:G or G:C to T:A transversion mutations, because 8-oxoG forms a stable basepair with adenine as well as with cytosine. OGG1 (for 8-oxoG DNA glycosylase), also designated MMH, is a DNA repair enzyme that corrects these mutations. Inactivation of the OGG1 gene leads to a mutator phenotype, characterized by the increase in G:C to T:A transversions. The OGG1 gene encodes 8 isoforms (OGG1A-C, OGG2A-E) which result from alternative splicing of a single messenger RNA. The OGG1A splice variant is the most prevalent form and localizes to the nucleus, whereas the OGG2A splice variant is targeted to the mitochondria.
OGG1/2 (G-20) 논문정보
OGG1/2 (G-20): sc-12076 antibody 및 OGG1/2 (G-20) antibody conjugates를 사용한 논문들을 보세요.
