ICMT Background Information ICMT (isoprenylcysteine carboxylmethyltransferase), also known as PCCMT, HSTE14 or PPMT, is a 284 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum and belongs to the isoprenylcysteine O-methyltransferase family. Expressed ubiquitously with highest expression in brain tissue, ICMT uses divalent cations (such as zinc) to catalyze the post-translational methylation of isoprenylated C-terminal cysteine residues. Specifically, ICMT functions as the third of three enzymes that modify isoprenylated C-terminal cysteine residues on target proteins, thereby targeting those proteins to the cell membrane. Inhibition of ICMT effects Ras function and causes endothelial apoptosis, an event that may lead to a decrease in oncogenic transformation. Multiple isoforms of ICMT exist due to alternative splicing.
ICMT (C-21)
클릭하시면 확대된 이미지를 보실 수 있습니다.
ICMT (C-21): sc-130150. Western blot analysis of ICMT expression in 293T (A) and HeLa (B) whole cell lysates.
ICMT (C-21): sc-130150. Western blot analysis of ICMT expression in T4D7D (A) and SK-BR-3 whole cell lysate (B).
