EDF1 Background Information Angiogenesis is the process of neovascularization and formation of new blood vessels from the established micro-circulation. Endothelial cell differentiation is required for angiogenesis. EDF1 (Endothelial differentiation-related factor 1), also known as MBF1 (Multiprotein-bridging factor 1) is a 148 amino acid transcriptional coactivator that modulates transcription of genes involved in endothelial differentiation. When endothelial cells are induced to differentiate in vitro, EDF1 is downregulated, leading to inhibition of cell growth and cell polarization. EDF1 binds calmodulin thorough its IQ domain and regulates nitric oxide synthase activity through calmodulin sequestration in the cytoplasm. Though ubiquitously expressed, EDF1 is most abundant in adult liver, heart, adipose tissues, intestine and pancreas. In fetal tissues, EDF1 is most abundant in kidney. There are two isoforms of EDF1 that are produced as a result of alternative splicing events.
EDF1 (U-21)
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EDF1 (U-21): sc-133536. Western blot analysis of EDF1 expression in Jurkat whole cell lysate.
