FAR1 Background Information MAP kinase cascades, consisting of a mitogen-activated protein kinase (also called ERK, for extracellular regulated kinase) and one or more upstream regulatory kinases (MAPKKs), play an integral role in signal transduction. The best characterized MAP kinase pathway to date is the yeast pheromone response pathway (1). Extracellular pheromones bind to the receptors Ste2 and Ste3 on the cell surface. Activation of these receptors eventually leads to stimulation of the MAPKKK Ste11 (2). Upon phosphorylation, Ste11 activates the MAPKK Ste7 (3), which in turn activates the MAP kinases Fus3 (also called Dac2) and Kss1 (4,5). These MAP kinases activate the transcription factor Ste12, which upregulates mating-specific genes (6,7), and Far1, which arrests the cell cycle (8).
FAR1 (B-23)
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FAR1 (B-23): sc-133573. Western blot analysis of FAR1 expression in Hep G2 whole cell lysate.
