santa cruz biotechnology, inc.
rabbit polyclonal IgG, 200 µg/ml epitope corresponding to amino acids 141-193 mapping within an internal region of L3MBTL2 of human origin recommended for detection of L3MBTL2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
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Species
유전자 이름 (Gene Name)
유전자 ID
염색체 위치
Isoform (mRNA) Accession #
Protein Accession #
OMIM™ Number
Human
L3MBTL2
83746
22q13.2
Q969R5
n/a
Mouse
L3mbtl2
214669
15 E1
P59178
없음
L3MBTL2 Background Information Polycomb group (PcG) proteins are important for maintaining the transcriptionally repressed state of target genes and are thought to function via chromatin modification. L3MBTL2 (Lethal(3)malignant brain tumor-like 2 protein), also known as L3MBT or H-l(3)mbt-l, is a 705 amino acid member of the PcG family. Localized to the nucleus, L3MBTL2 associates with chromatin-remodeling complexes and helps inhibit the expression of proteins that trigger the cell to enter mitosis. During the G0 phase of the cell cycle, L3MBTL2 is part of a complex that contains other proteins (such as HP1©, E2F-6 and Max) that participate in transcriptional repression. L3MBTL2 contains one FCS-type zinc finger and four MBT repeats and is expressed as three isoforms due to alternative splicing events.