epitope mapping near the N-terminus of Fox-1 of human origin
recommended for detection of Fox-1 isoforms 1-5 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine and porcine
Fox-1 Background Information Fox-1, also known as A2BP, A2BP1 or HRNBP1, is a 397 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one RRM domain. Expressed predominately in muscle and brain tissue, Fox-1 interacts with Ataxin-2 and functions as an RNA-binding protein that regulates alternative splicing events during erythropoiesis, specifically by binding to 5'-UGCAUGU-3' DNA elements. Multiple isoforms of Fox-1 exist due to alternative splicing events. The gene encoding Fox-1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
