epitope mapping near the N-terminus of EBF of human origin
recommended for detection of EBF1 and EBF3 of mouse, rat and human origin by ELISA; also reactive with additional species, including bovine and porcine
EBF Background Information B lymphocyte maturation is an intricate process that requires a distinct set of transcription factors with respect to the stage of cell differentiation and cell lineage. Among the transcriptional regulators involved in the early stages of B cell development, early B cell factor (EBF), also designated olfactory neuronal transcription factor 1 (OLF1), targets promoter elements for B lymphoid kinase (Blk) and genes encoding portions of the early stage B cell receptors (BCR), which are necessary for initiation of Ig light chain gene recombination and Src kinase (Blk) signaling. EBF is a basic helix-loop-helix (bHLH) homodimeric transcription factor composed of two subunits that interact with the core DNA sequence, CCCNNGGG, through a DNA recognition domain containing a zinc-coordination motif. Promoter elements to certain neuron-specific genes encoding olfactory-related proteins have been shown to contain EBF binding sites.
EBF (N-20) 논문정보
EBF (N-20): sc-15886 antibody 및 EBF (N-20) antibody conjugates를 사용한 논문들을 보세요.
