epitope mapping near the C-terminus of CTCF of human origin
recommended for detection of CTCF of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
blocking peptide, sc-15914 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-15914 X, 200 µg/0.1 ml
CTCF Background Information CTCF belongs to the zinc finger transcription factor family, and it recognizes unusually long and remarkably divergent DNA target sequences to influence expression of many various genes. The DNA-binding domain of CTCF is composed of 11 Zn fingers including 10 that are of C2H2 class, and 1 that is of C2HC class, and they are highly conserved between vertebrate species. CTCF functions as a repressor of the c-myc gene and as a regulator of lysozyme gene expression. In addition, CTCF associates with the essential activator domain in the promotor region of the amyloid beta-protein precursor (APP) gene to activate transcription of APP. Expression of CTCF up-regulates APP expression and thereby, enhances synapse formations between primary neurons during development. CTCF is ubiquitously expressed and localized to the nucleus. During terminal differentiation, CTCF is negatively regulated by differential phosphorylation and also by decreases in CTCF mRNA and protein expression.
CTCF (C-20) 논문정보
CTCF (C-20): sc-15914 antibody 및 CTCF (C-20) antibody conjugates를 사용한 논문들을 보세요.
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CTCF (C-20)
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CTCF (C-20): sc-15914. Western blot analysis of CTCF expression in CCRF-CEM nuclear extract.
CTCF (C-20): sc-15914. Western blot analysis of CTCF expression in non-transfected: sc-117752 (A) and mouse CTCF transfected: sc-119494 (B) 293T whole cell lysates.
CTCF (C-20): sc-15914. Western blot analysis of CTCF expression in non-transfected: sc-117752 (A) and human CTCF transfected: sc-170327 (B) 293T whole cell lysates and Jurkat nuclear extract (C).
CTCF (C-20): sc-15914. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
