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- goat polyclonal IgG, 200 µg/ml
- epitope mapping within an internal region of β-1,4-Gal-T7 of human origin
- recommended for detection of β-1,4-Gal-T7 of mouse, rat and human origin by WB, IP, IF and ELISA; non cross-reactive with other β-1,4-Gal-T family members; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-160112 P
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주문정보
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β-1,4-Gal-T7 Background Information
∫-1,4-galactosyltransferases (∫-1,4-Gal-T) are type II membrane-bound glycoproteins that are substrate-specific and function to transfer galactose in a ∫-1,4 linkage to an acceptor sugar. There are seven members of the ∫-1,4-Gal-T family, all of which are directed to the golgi apparatus through a hydrophobic sequence at the N-terminus. ∫-1,4-Gal-T7, also known as B4GALT7 or XGALT1, is a 327 amino acid single-pass type II membrane protein that is expressed at high levels in heart, pancreas and liver. ∫-1,4-Gal-T7 uses manganese to catalyze the UDP-dependent biosynthesis of glycosphingolipids. The gene encoding ∫-1,4-Gal-T7 is mutated in Ehlers-Danlos syndrome progeroid type (EDSP), a variant form of Ehlers-Danlos syndrome characterized by progeroid facies, mild mental retardation, short stature, skin hyperextensibility, moderate skin fragility, joint hypermobility principally in digits. |
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β-1,4-Gal-T7 (P-12)
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β-1,4-Gal-T7 (P-12): sc-160112. Western blot analysis of β-1,4-Gal-T7 expression in mouse skeletal muscle tissue extract.
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다운로드
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