epitope mapping at the N-terminus of NAP125 of human origin
recommended for detection of NAP125 of human origin and Nap1 of mouse origin of mouse, rat and human origin by WB, IP, IF and ELISA; non cross-reactive with NAP5; also reactive with additional species, including avian
NAP125 Background Information NAP125, also known as NCKAP1 (NCK-associated protein 1), p125Nap1 or membrane-associated protein HEM-2, is a 1,128 amino acid single pass membrane protein that exists as two alternatively spliced isoforms and belongs to the HEM-1/HEM-2 family. While widely expressed, NAP125 is found at highest levels in heart, brain and skeletal muscle where it regulates Rac-dependent actin remodeling as part of a lamellipodial complex with WAVE2, Abi-1 and CYFIP1. NAP125 localizes to the cytoplasmic side of lamellipodium membrane and is encoded by a gene that maps to human chromosome 2q32.1 and mouse chromosome 2 C3. NAP125 expression is markedly reduced in Alzheimer disease (AD)-affected brains, suggesting a possible role in the disease.
NAP125 (N-12)
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NAP125 (N-12): sc-161124. Western blot analysis of NAP125 expression in C2C12 whole cell lysate.
