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홈 » 화학 시약 (Chemicals) » Dual LO/CO Inhibitors » Meclofenamate sodium: sc-200532

Meclofenamate sodium: sc-200532

  |  Datasheet (데이터 시트)  | MSDS
  • Specifications
    • 로/으로 공급 1 g (sc-200532) 와/과 5 g (sc-200532A) 사이즈
    • CAS 번호: 6385-02-0
    • 분자량 (Molecular Weight): 318.1
    • 분자식: C14H10Cl2NO2 ·Na
    • 순도: >99%
    • 부터/로부터: Solid
    • 물질상태: White solid
    • 용해도: Water (15 mg/ml)
    • SMILES: CC1=C(C(=C(C=C1)Cl)NC2=CC=CC=C2C(=O)[O-])Cl.[Na+]
  • Description (설명)
    • Meclofenamate sodium is a dual inhibitor of the 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways. Meclofenamate sodium is demonstrated to inhibit both COX-1 and COX-2, showing micromolar inhibition of human recombinant hCOX-1 (IC50 = 1.5 μM) and hCOX-2 (9.7 μM). An irreversible time-dependent inhibition of hCOX-2 is described, involving a rapid equilibrium binding of enzyme and inhibitor followed by formation of a tightly bound inhibited complex.
  • 저장온도
    • Store at room temperature
  • 특성
    • 용해점: 289–291 ºC
  • 안전
    • 독성물질등록번호 (RTECS): CB2975500
  • 연구용으로만 사용
    • The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
  • 참조번호
    • PubChem Compound ID: 4038
    • Merck Index: 14: 5779
    • MDL 번호: MFCD00077376
    • EC 번호: 228-983-3
  • References
    • 1. Rampart, M.,etal. 1986. Biochem. Pharmacol. 35: 581-586. PMID: 3081008
      2. Boctor, A.M., et al. 1986. Prostaglandins Leukot Med. 23: 229-238. PMID: 3020588
      3. Laneuville, O., et al. 1994. J. Pharmacol. Exp. Ther. 271: 927-934. PMID: 7965814
      4. Ouellet, M. and Percival, M.D. 1995. Biochem. J. 306: 247-251. PMID: 7864817
      5. Narsinghani, T., et al. 2006. Bioorg. Med. Chem. Lett. 16: 461-468. PMID: 16290292
 
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Meclofenamate sodium sc-200532 1 g $21
Meclofenamate sodium sc-200532A 5 g $61
Meclofenamate sodium
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Meclofenamate sodium
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