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- Specifications
- 로/으로 공급 50 mg (sc-204192)
- CAS 번호: 737-86-0
- 분자량 (Molecular Weight): 286.29
- 분자식: C14H14N4O3
- 순도: ≥99%
- 부터/로부터: Solid
- 물질상태: Yellow solid
- 용해도: Solubility: Soluble in DMSO (5 mg/ml) or slightly acidic medium
- SMILES: CC1=NC=C(C(=CNNC(=O)C2=CC=NC=C2)C1=O)CO
- Description (설명)
- A cell-permeable, non-toxic, iron (Fe3+) chelator of the aroyl hydrazone class that exhibits high chelation efficacy. Highly effective in mobilizing Fe3+ from cells and even at low concentrations, prevents its uptake from transferrin. Exhibits similar binding affinity and specificity as Desferrioxamine, but has greater access to mitochondrial iron. Prevents iron-mediated oxyradical formation and minimizes tissue damage. Reported to useful in studies of the management of iron overload disease. Inhibits the induction of heme-containing indoleamine 2,3-dioxygenase activity.
- 저장온도
- Store at 4° C. Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. Acidic stock solutions are stable for up to 2 months at -20°C.
- 연구용으로만 사용
- 참조번호
- References
- Buss, J.L., et al. 2002. Biochem. Pharmacol. 64, 1689.
Thomas, S.R., et al. 2001. J. Immunol. 166, 6332.
Hermes-Linda, M., et al. 2000. Biochim. Biophys. Acta 1523, 154.
Blaha, K., et al. 1998. Blood 11, 4368.
Richardson, D.R., and Ponka, P. 1998. J. Lab. Clin. Med. 131, 306.
Richardson, D.R.,et al. 1995. Blood 86, 4295.
Richardson, D.R., et al. 1994. J. Lab. Clin. Med. 124, 660.
Ponka, P., et al. 1988. Biochim. Biophys. Acta 967, 122.
Ponka, P., et al. 1984. Biochim. Biophys. Acta 802, 477.
Ponka, P., et al. 1979. FEBS Lett. 97, 317.
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Pyridoxal Isonicotinoyl Hydrazone
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