Amylin Background Information Adrenomedullin (AM), alpha- and beta-calcitonin gene-related peptide (CGRP), calcitonin (CT) and Amylin are homologous polypeptides with overlapping biological actions, such as vasodilatation and inhibition of bone resorption. Amylin (Islet/insulinoma amyloid polypeptide or IAPP) is a 37 amino acid monomeric polypeptide isolated from pancreatic amyloid. This protein is a major component of amyloid-rich pancreatic extracts of type 2 diabetic patients. Amylin has cysteine residues in positions 2 and 7, a feature found in all known calcitonin gene-related peptides, and shows 46% amino acid sequence homology with CGRP II. Demonstrated immunochemically in normal beta cells of several mammals, Amylin likely plays an important role in pancreatic islet function. The gene that encodes Amylin maps to human chromosome 12p12.3-p12.1.
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Amylin (H-50)
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Amylin (H-50): sc-20936. Western blot analysis of human recombinant Amylin fusion protein.
