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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 1-300 mapping at the N-terminus of MCM6 of human origin
- recommended for detection of MCM6 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine and bovine
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주문정보논문정보
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| Species |
유전자 이름 (Gene Name) |
유전자 ID |
염색체 위치 |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
MCM6 |
4175 |
2q21.3 |
NM_005915 |
Q14566
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n/a |
| Mouse |
Mcm6 |
17219 |
1 E4 |
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P97311
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없음 |
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MCM6 Background Information
The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the postreplicative state of the cell. MCM2/MCM4 complexes function as substrates for Cdc2/cyclin B in vitro. Cleavage of MCM3, which can be prevented by caspase inhibitors, results in the inactivation during apoptosis of the MCM complex, which is composed of, at least, MCM2–6. A complex composed of MCM4, MCM6 and MCM7 has been shown to be involved in DNA helicase activity, and MCM5 is involved in IFN-©-induced Stat1å transcription activation.
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MCM6 (H-300): sc-22781 antibody 및 MCM6 (H-300) antibody conjugates를 사용한 논문들을 보세요.
3 total citations 논문 자료 로드 중입니다.
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MCM6 (H-300)
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MCM6 (H-300): sc-22781. Western blot analysis of MCM6 expression in MM-142 whole cell lysate.
MCM6 (H-300): sc-22781. Western blot analysis of MCM6 expression in Daudi (A), KNRK (B), ALL-SIL (C) and K-562 (D) whole cell lysates.
MCM6 (H-300): sc-22781. Western blot analysis of MCM6 expression in Daudi (A), KNRK (B), ALL-SIL (C) and K-562 (D) whole cell lysates.
MCM6 (H-300): sc-22781. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
MCM6 (H-300): sc-22781. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cervical cancer tissue showing nuclear staining of tumor cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
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