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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 322-381 mapping at the C-terminus of EDG-1 of human origin
- recommended for detection of EDG-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- agarose conjugate for IP studies, sc-25489 AC, 500 µg/0.25 ml agarose
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주문정보논문정보
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| Species |
유전자 이름 (Gene Name) |
유전자 ID |
염색체 위치 |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
EDG1 |
1901 |
1p21.2 |
NM_001400 |
P21453
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601974 |
| Mouse |
S1pr1 |
13609 |
3 G1 |
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O08530
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없음 |
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EDG-1 Background Information
The EDG (endothelial differentiation gene) family of G protein coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high affinity. EDG-6 is a low affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. EDG-6, which is expressed in lymphoid and hematopoietic tissues and in lung, signals through G(i/o) proteins, which activate growth related pathways.
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EDG-1 (H-60): sc-25489 antibody 및 EDG-1 (H-60) antibody conjugates를 사용한 논문들을 보세요.
9 total citations 논문 자료 로드 중입니다.
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EDG-1 (H-60)
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EDG-1 (H-60): sc-25489. Western blot analysis of human recombinant EDG-1 fusion protein.
EDG-1 (H-60): sc-25489. Western blot analysis of EDG-1 expression in mouse brain (A) and rat brain (B) tissue extracts.
EDG-1 (H-60): sc-25489. Western blot analysis of EDG-1 expression in human brain tissue extract.
EDG-1 (H-60): sc-25489. Western blot analysis of EDG-1 expression in non-transfected: sc-117752 (A) and mouse EDG-1 transfected: s-119919 (B) 293T whole cell lysates. EDG-1 (H-60): sc-25489. Western blot analysis of EDG-1 expression in non-transfected: sc-117752 (A) and mouse EDG-1 transfected: sc-119919 (B) 293T whole cell lysates. |
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