epitope mapping near the C-terminus of GCL of mouse origin
recommended for detection of GCL and GMCL1L of human origin and GCL of mouse and rat origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
GCL Background Information Germ cell-less (GCL) represses transcription during the later stages of spermatogenesis both in Drosophila and mammalian species. GCL localizes to the nuclear envelope, where it competes with BAF to interact with emerin,
a complex that is required for appropriate gene expression. Defective sperm motility as well as impaired nuclear envelope integrity in liver, pancreas and testis cells result from a lack of GCL gene expression. Thus it appears that the essential function of GCL is to facilitate normal nuclear-lamina organization, which results in normal sperm morphogenesis and chromatin remodeling.
GCL (L-15)
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GCL (L-15): sc-27689. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
