NAB2 Background Information Transcriptional control is in part regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (for NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2 are corepressors of EGF-1/NGFI-A. Both NAB1 and NAB2 contain an amino terminal NAB conserved domain 1 (NCB1), which is required for binding NGFI-A, and a carboxy terminal NCD2 domain, which is responsible for the repressor function of NAB proteins. NAB2 is principally localized in the nucleus and may play a role in the downregulation of NGFI-A activity as well as in controlling fundamental processes such as cell division, differentiation and apoptosis. NAB2 localizes to chromosome 12q13.3-14.1, a region that is rearranged in several solid tumors, lipomas, and liposarcomas.
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NAB2 (C-6)
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NAB2 (C-6): sc-28323. Western blot analysis of NAB2 expression in K-562 (A) and Rat2 (B) whole cell lysates.
NAB2 (C-6): sc-28323. Immunoperoxidase staining of formalin fixed, paraffin-embedded human endometrium tissue showing nuclear staining in cells in endometrial stroma. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
NAB2 (C-6): sc-28323. Western blot analysis of NAB2 expression in non-transfected 293T: sc-117752 (A), human NAB2 transfected 293T: sc-117107 (B) and K-562 (C) whole cell lysates.
