BAP1 Background Information Mutations within the BRCA1 gene, localized to chromosome 17q, are believed to account for approximately 45% of families with increased incidence of both early-onset breast cancer and ovarian cancer. The BRCA1 gene is expressed in numerous tissues, including breast and ovary, and encodes a predicted protein of 1863 amino acids. This protein contains a RING domain near the N-terminus and appears to encode a tumor suppressor. BARD1 (BRCA1-associated RING domain protein 1) and BAP1 (BRCA1-associated protein 1) have both been shown to bind to the N-terminus of BRCA1 and are potential mediators of tumor suppression. BARD1 contains an N-terminal RING domain and three tandem ankyrin repeats. The C-terminus of BARD1 contains a region with sequence homology to BRCA1, termed the BRCT domain. BAP1 is a ubiquitin hydrolase and has been shown to enhance BRCA1-mediated cell growth suppression.
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BAP1 (C-4)
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BAP1 (C-4): sc-28383. Western blot analysis of BAP1 expression in SK-BR-3 (A), IB4 (B) and KNRK (C) whole cell lysates.
aBAP1 (C-4): sc-28383. Immunoperoxidase staining of formalin fixed, paraffin-embedded human duodenum tissue showing nuclear staining of glandular cells (low and high magni?fication). Kindly provided by The Swedish Human Protein Atlas (HPA) program.
BAP1 (C-4): sc-28383. Western blot analysis of BAP1 expression in non-transfected: sc-117752 (A) and human BAP1 transfected: sc-171879 (B) 293T whole cell lysates.
