TERE1 Background Information Transitional epithelial response protein 1 (TERE1), also designated UbiA prenyltransferase domain containing protein 1 (UBIAD1), belongs to the UbiA prenyltransferase family of proteins. The gene encoding for the protein is similar to the Drosophila protein heix, and influences progression of prostate and bladder cancers. There appears to be a decrease in TERE1 transcript in prostate carcinoma and a loss of the TERE1 protein in metstatic prostate. It is a ubiquitously expressed multi-pass membrane protein but it can also be detected in the cytoplasm or nucleus. The TERE1 transcript (1.5 and 3.5 kb) is present in most normal human tissues, including Urothelium.
