MDA5 (C-16) Antibody (항체): sc-48031

MDA5 Background Information
The gene that encodes MDA5 (interferon induced with helacase C domain protein 1, IFIH1, melanoma differentiation-associated gene 5) is induced during differentiation, cancer reversion, and programmed cell death (apoptosis) and contains both a caspase recruitment domain and supposed DExH group RNA helicase domains. The irregular helicase motifs of MDA5 avert from consensus sequences but are well conserved in a potentially new group of cloned and hypothetical proteins. MDA5 is an early response gene which is activated by IFN and tumor necrosis factor å, and responds primarily to IFN-∫. Expression of MDA5 is upregulated in the presence of MEZ (a protein kinase C activating compound). Expression of MDA5 in tissues is low overall, with highest levels observed in the placenta, pancreas and spleen; MDA5 is undetectable in brain, lung and testis tissues. MDA5 also recognizes polyinosine-polycytidylic acid and RNA viruses while playing a critical role in picornavirus detection.