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- goat polyclonal IgG, 200µg/ml
- epitope mapping near the C-terminus of Ferrochelatase of human origin
- recommended for detection of mitochondrial precursor and mature Ferrochelatase of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-49663 P
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Ferrochelatase Background Information
Ferrochelatase, also designated Heme synthetase or protoheme ferro-lyase, is the terminal enzyme of protoheme biosynthesis that catalyzes the ferrous form of iron insertion into protoporphyrin IX. Mature ferrochelatase is a homodimeric, mitochondrial membrane-associated protein translated downstream of an N-terminal 54-amino acid transit peptide. Ferrochelatase contains two nitric oxide (NO)-sensitive clusters and coordinated 2FE-2S clusters which may potentially serve as a nitric oxide sensor. Defects in the gene encoding the Ferrochelatase enzyme, FECH, cause erythropoietic protoporhyria (EPP), which is a dominantly inherited disease of porphyrin metabolism characterized by photosensitivity and hepatobiliary disease. |
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Ferrochelatase (C-20)
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Ferrochelatase (C-20): sc-49663. Western blot analysis of Ferrochelatase expression in non-transfected: sc-117752 (A) and human Ferrochelatase transfected: sc-115804 (B) 293T whole cell lysates. errochelatase (C-20): sc-49663. Immunoperoxidase staining of formalin fixed, paraffin-embedded human esophagus tissue showing cytoplasmic staining of squamous epithelial cells in low (A) and high (B) resolution. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
Ferrochelatase (C-20): sc-49663. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic and nuclear localization.
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