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- goat polyclonal IgG, 200µg/ml
- epitope mapping at the C-terminus of OAS1 p41 of human origin
- recommended for detection of OAS1 p41 isoform of human origin by WB, IP, IF and ELISA
- TransCruz reagent for Gel Supershift and ChIP applications, sc-49849 X, 200 µg/0.1 ml
- blocking peptide, sc-49849 P
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주문정보
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OAS1 Background Information
The 2'-, 5'- oligoadenylate synthetases (OASs) are interferon-induced proteins that play a putative role in mediating resistance to virus infection, control of cell growth, differentiation and apoptosis. OAS1, which functions as a homotetramer, is characterized by its capacity to catalyze the synthesis of 2'-, 5'- oligomers of adenosine (2-5As). OAS1 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, activating latent RNase L which, when activated, cleaves single-stranded RNAs. This RNase L activity leads to the inhibition of cellular protein synthesis and the impairment of viral replication. OAS1, a 400 amino acid containing protein, is also important in evaluating the interferon response in RNAi studies, and is implicated in diabetes mellitus susceptibility. |
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OAS1 (V-18)
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OAS1 (V-18): sc-49849. Western blot analysis of OAS1 expression in non-transfected: sc-110760 (A) and human OAS1 transfected (B) 293 whole cell lysates. |
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