epitope corresponding to amino acids 1-160 mapping within an N-terminal extracellular domain of vezatin of human origin
recommended for detection of vezatin of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine and porcine
vezatin Background Information Vezatin is a single transmembrane domain containing mammalian adhesion protein that is ubiquitously expressed at adherens cell-cell junctions (1,2). Adherens junctions (zonula adherens) are cell-cell junctions that host microfilaments and/or intermediate filaments, which can coordinate with focal adhesion proteins and mediate tissue organization and morphogenesis (3-5). Vezatin interacts with actin filamentous networks and anchors myosin VIIA to cadherin complexes, thereby creating a network between adherens junctions and the actin cytoskeleton. This may enhance cell-cell adhesion characteristics and influence cadherin-based signals (1). Vezatin is concentrated in the fibrillar links interconnecting the bases of adjacent stereocilia in the inner ear sensory hair cells and may mediate proper positioning of hair cell stereocilia (1). Loss of a functional vezatin-myosin VIIa complex at both the adherent junctions and the base of the stereocilia is likely to account for the splaying out of the stereocilia observed in Myo7a-/- animals. Vezatin recruitment to adherens junctions implicates the C-terminal region of alpha-catenin.
vezatin (H-160)
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vezatin (H-160): sc-50434. Western blot analysis of vezatin expression in non-transfected 293T: sc-117752 (A), human vezatin transfected 293T: sc-117118 (B) and HeLa (C) whole cell lysates.
