epitope mapping within an internal region of Glyoxalase II of human origin
recommended for detection of Glyoxalase II of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and avian
Glyoxalase II Background Information The glyoxal pathway plays a role in the detoxification of glucose degradation products (GDP). Glyoxalase I and Gyloxalase II (also designated hydroxyacyl glutathione hydrolase or HAGH) are members of the Gyloxalase family. The Gyloxalase II enzyme is a thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form reduced glutathione and D-lactic acid. It exists only as a monomer and binds two zinc ions per subunit. Glyoxalase II contains 260 amino acids. It is detected in the mitochondria and cytosol of mammals. Both Glyoxalase I and Gyloxalase II are detected at a higher activity level in breast cancer tissues than with matched unaffected tissues. This suggests that glyoxalase inhibitor drugs may be effective in the treatment of cancer.
Glyoxalase II (G-20)
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Glyoxalase II (G-20): sc-51092. Western blot analysis of Glyoxalase II expression in non-transfected: sc-117752 (A) and mouse Glyoxalase II transfected: sc-120531 (B) 293T whole cell lysates.
Glyoxalase II (G-20): sc-51092. Western blot analysis of Glyoxalase II expression in Hep G2 whole cell lysate.
Glyoxalase II (G-20): sc-51092. Western blot analysis of Glyoxalase II expression in non-transfected: sc-117752 (A) and human Glyoxalase II transfected: sc-170335 (B) 293T whole cell lysates.
Glyoxalase II (G-20): sc-51092. Western blot analysis of Glyoxalase II expression in non-transfected: sc-117752 (A) and human Glyoxalase II transfected: sc-159999 (B) 293T whole cell lysates.
