epitope mapping near the C-terminus of ALR of human origin
recommended for detection of ALR of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
ALR Background Information ALR (augmenter of liver regeneration), also called Erv1-like growth factor, hepatopoietin (HPO) or hepatic regenerative stimulation substance (HSS), is a hepatotrophic growth factor and flavin-linked sulfhydryl oxidase expressed in various tissues. ALR exists as a homodimer and belongs to the Erv1/ALR family of proteins. This family can be found in higher and lower eukaryotes. ALR has two forms: a cytosolic form and a nuclear form. The nuclear form regulates the transcriptional activity of AP-1. The cytosolic form plays a role in the biogenesis of Fe/S proteins and contributes to cellular iron homeostasis. In addition, ALR induces the expression of S-adenosylmethionine decarboxyl-ase and ornithine decarboxylase (ODC), which each play an important role in the synthesis of polyamines. Through stimulation of polyamine synthesis, ALR heavily contributes to the regulation of the different stages of liver regeneration.
ALR (V-16)
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ALR (V-16): sc-51257. Western blot analysis of ALR expression in Hep G2 whole cell lysate (A) and rat liver (B) and mouse liver (C) tissue extracts.
ALR (V-16): sc-51257. Western blot analysis of ALR expression in non-transfected 293T: sc-117752 (A), mouse ALR transfected 293T: sc-118366 (B) and Hep G2 (C) whole cell lysates.
ALR (V-16): sc-51257. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.
