 |
- rabbit polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of JAK3 of human origin
- recommended for detection of JAK3 of human origin by WB, IP, IF and ELISA
- blocking peptide, sc-513 P
- TransCruz reagent for ChIP application, sc-513 X, 200 µg/0.1 ml
- agarose conjugate for IP studies, sc-513 AC, 500 µg/0.25 ml agarose
|
|
| |
주문정보논문정보
추천하는 보조제품:
원하시는 application에 클릭해 주세요.
| |
| Species |
유전자 이름 (Gene Name) |
유전자 ID |
염색체 위치 |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
JAK3 |
3718 |
19p13.11 |
NM_000215 |
P52333
|
600173 |
| |
JAK3 Background Information
JAK3 (Janus kinase 3) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK3. JAK3 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system, stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.
|
JAK3 (C-21): sc-513 antibody 및 JAK3 (C-21) antibody conjugates를 사용한 논문들을 보세요.
43 total citations 논문 자료 로드 중입니다.
|
| |
|
|
|
JAK3 (C-21)
클릭하시면 확대된 이미지를 보실 수 있습니다.
|
|
JAK3 (C-21): sc-513. Western blot analysis of JAK3 expression in HuT 78 (A) and MOLT-4 (B) whole cell lysates.
Western blot analysis of JAK3 expression in HeLa whole cell lysates (A,B). Antibodies tested include JAK3 (B-12): sc-6932 (A) and JAK3 (C-21): sc-513 (B). JAK3 (C-21): sc-513. Western blot analysis of JAK3 expression in HuT 78 whole cell lysate.
|
|
다운로드
|
|
