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- mouse monoclonal IgG2b; 200 µg/ml
- raised against amino acids 1-134 of Oct-3/4 of human origin
- recommended for detection of Oct-3/4 of mouse, rat and human origin by WB, IP, IF, IHC(P), ELISA and indirect FCM using PE-conjugated goat anti-mouse IgG: sc-3738; non cross-reactive with Oct-3/4 isoform B
- agarose conjugate for IP studies, sc-5279 AC, 500 µg/0.25 ml agarose
- TransCruz reagent for Gel Supershift and ChIP applications, sc-5279 X, 200 µg/0.1 ml
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주문정보논문정보
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Oct-3/4 Background Information POU5F1 (POU domain, class 5, transcription factor 1), also known as octamer-binding transcription factor-3 (Oct-3, Otf-3), octamer-binding transcription factor-4 (Oct-4, Otf-4) and Oct-3/4, modulates embryonic stem (ES) cell populations by influencing lineage commitment. Oct-3/4 sustains stem-cell self-renewal and differentiation pathways. Transcription factors containing the POU homeodomain regulate tissue-specific gene expression in lymphoid and pituitary differentiation and in early mammalian development. Oct-3/4 is capable of inducing rapid proliferation and tumorigenic properties of ES cells through activation of the UTF1 gene. In humans, two Oct-3/4 isoforms contribute to influencing the undifferentiated phenotype of ES cells. Oct-3/4 pseudogenes localizing to human chromosomes 10 and 8 are reported to be transcribed in certain cancer cell lines and tissues.
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Oct-3/4 (C-10): sc-5279 antibody 및 Oct-3/4 (C-10) antibody conjugates를 사용한 논문들을 보세요.
110 total citations 논문 자료 로드 중입니다.
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Oct-3/4 (C-10)
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Oct-3/4 (C-10): sc-5279. Indirect, intracellular FCM analysis of fixed and permeabilized F9 cells stained with Oct-3/4 (C-10), followed by PE-conjugated goat anti-mouse IgG: sc-3738. Black line histogram represents the isotype control, normal mouse IgG 2b: sc-3879.
Oct-3/4 (C-10): sc-5279. Immunofluorescence staining of paraformaldehyde fixed multicell mouse embryo showing nuclear localization. Kindly provided by Dr. Kira Foygel, Stanford University.
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