epitope mapping within an internal region of HAPLN2 of human origin
recommended for detection of HAPLN2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine and porcine
HAPLN2 Background Information HAPLN2 (hyaluronan and proteoglycan link protein 2, brain link protein 1) is a 340 amino acid protein encoded by the human gene HAPLN2. HAPLN2 belongs to the HAPLN family and contains one immunoglobulin (Ig)-like, V-type domain and two link domains. HAPLN2 mediates a firm binding of versican V2 to hyaluronic acid. HAPLN2 is believed to play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS), which facilitates neuronal conduction and general structural stabilization. HAPLN2 may also be involved in the formation of extracellular matrices, contributing to perineuronal nets and facilitating the understanding of a functional role of these extracellular matrices. HAPLN2 is found in several nuclei throughout the midbrain and hindbrain in a perineuronal net pattern.
HAPLN2 (T-20)
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HAPLN2 (T-20): sc-55105. Western blot analysis of HAPLN2 expression in non-transfected: sc-117752 (A) and human HAPLN2 transfected: sc-114486 (B) 293T whole cell lysates.
