IL-12 p70 (QS-12p70) Antibody (항체): sc-57257

IL-12 p70 Background Information
The interleukins (ILs) are a broad family of well characterized cytokines, primarily of hematopoietic cell origin. As new cytokines are molecularly characterized, they are assigned an IL number to maintain a standard nomenclature. ILs are secreted by immune cells that regulate a wide range of immune system functions. IL-12 is secreted by macrophages and human B-lymphoblastoid cells in response to antigenic stimulation. This IL is responsible for the differentiation of naive CD4(+) T cells into type 1 helper T cells that produce interferon-© (IFN-©). It also activates production of tumor necrosis factor å (TNF-å) from T and natural killer (NK) cells, and it inhibits IL-4 mediated suppression of IFN-©. IL-12 also has anti-angiogenic activity since the production of IFN-© increases the production of inducible protein-10 (IP-10). IL-12 p40 represents a subunit of this IL that is induced by several pathogens. IL-12 p70 is a subunit of IL-12 that is controlled through both the p35 and p40 genes in a cell type-specific fashion.