epitope mapping at the C-terminus of Gab 1 of human origin
recommended for detection of Gab 1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
Gab 1 Background Information Growth factor triggering of protein tyrosine kinase receptors induces signals that cascade to the nucleus, activating mitogenic as well as other responses. Critical components of this process include adapter proteins such as Shc, IRS-1 and Gab 1 (GRB-associated binder-1) that lack detectable catalytic activity (1-3,8). These are immediate substrates of receptor tyrosine kinase activity and serve to link activated receptors to downstream signaling components. Whereas Shc has been implicated in signaling by diverse receptor families, IRS-1 serves primarily as the major insulin receptor substrate (4-7). Shc and Gab 1 also participate in insulin signaling by linking the insulin receptor to Ras by forming complexes with GRB2 (another adapter protein) and Sos independently of IRS-1. Gab 1 is also thought to be involved in the EGF receptor signaling pathway (7,8).
Gab 1 (C-20) 논문정보
Gab 1 (C-20): sc-6292 antibody 및 Gab 1 (C-20) antibody conjugates를 사용한 논문들을 보세요.
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Gab 1 (C-20)
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Gab 1 (C-20): sc-6292. Western blot analysis of Gab 1 expression in HeLa (A) and NIH/3T3 (B) whole cell lysates.
Gab 1 (C-20): sc-6292. Western blot analysis of Gab 1 expression in non-transfected: sc-117752 (A) and human Gab 1 transfected: sc-111467 (B) 293T whole cell lysates.
Gab 1 (C-20): sc-6292. Western blot analysis of Gab 1 expression in non-transfected: sc-117752 (A) and mouse Gab 1 transfected: sc-120377 (B) 293T whole cell lysates.
Gab 1 (C-20): sc-6292. Western blot analysis of Gab 1 expression in non-transfected: sc-117752 (A) and human Gab 1 transfected: sc-111467 (B) 293T whole cell lysates.
