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- goat polyclonal IgG, 200µg/ml
- epitope mapping near the N-terminus of LASS5 of human origin
- recommended for detection of LASS5 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for Gel Supershift and ChIP applications, sc-65124 X, 200 µg/0.1 ml
- blocking peptide, sc-65124 P
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주문정보
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원하시는 application에 클릭해 주세요.
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| Species |
유전자 이름 (Gene Name) |
유전자 ID |
염색체 위치 |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
LASS5 |
91012 |
12q13.13 |
NM_147190 |
Q8N5B7
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n/a |
| Mouse |
Lass5 |
71949 |
15 F1 |
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Q9D6K9
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없음 |
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LASS5 Background Information
The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they are all involved in sphingolipid synthesis. LASS5, also called TRH4, is a 392 amino acid endoplasmic reticulum, multi-pass membrane protein. On the luminal side of the endoplasmic reticulum membrane, the N-terminal asparagine residue is glycosylated. Functioning as a bona fide (dihydro)ceramide synthase, LASS5 increases the levels of short ceramide species, such as C14:0- and C16:0-ceramides as well as those selectively enriched in palmitic acid. LASS5 is the most abundantly expressed longevity assurance homolog in lung epithelia where it functions as a regulator of PtdCho metabolism. In cells deficient for CLN9, as observed in neuronal ceroid lipofuscinosis (NCL) or Batten disease, LASS5 can increase ceramide levels and partially correct growth and apoptosis. |
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LASS5 (N-14)
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LASS5 (N-14): sc-65124. Western blot analysis of LASS5 expression in HeLa (A) and Jurkat (B) whole cell lysates and HeLa (C) and Jurkat (D) nuclear extracts.
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다운로드
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