santa cruz biotechnology, inc.
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- mouse monoclonal IgG1k, 100µg/ml
- raised against IFN-α2 of human origiin
- recommended for detection of natural and recombinant IFN-α2 of human origin by ELISA; non cross-reactive with IFN-α8, IFN-α21, or IFN-w
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주문정보
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| Species |
유전자 이름 (Gene Name) |
유전자 ID |
염색체 위치 |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
IFNA2 |
3440 |
9p21.3 |
NM_000605 |
P01563
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147562 |
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IFN-α2 Background Information
The genes encoding type I interferons (IFNs), which include 14 IFN-å genes (one of which is IFN-å2), 1 IFN-∫ gene, 1 IFN-w (also known as IFN-å II1) gene and a number of IFN-w pseudogenes, are clustered on human chromosome 9. IFN-å and -∫ are cytokines that are widely known to induce potent antiviral activity. They exert a variety of other biological effects, including antitumor and immunomodulatory activities and are increasingly used clinically to treat a range of malignancies, myelodysplasias and autoimmune diseases. IFN-w is antigenically different from human IFN-å, IFN-∫ or IFN-©, but is a component of natural mixtures of IFN species produced by virus-induced leukocytes or Burkitt's lymphoma cells. The type I interferon receptor (IFN-åR) interacts with IFN-å, IFN-∫ and IFN-w, and seems to be a multisubunit receptor. |
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