ADH (1.BB.974) Antibody (항체): sc-70325

ADH Background Information
The alcohol dehydrogenase family of proteins metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. ADH catalyzes the reversible conversion of organic alcohols to ketones or aldehydes. The three genes that encode the alpha (ADH1A), beta (ADH1B) and gamma (ADH1C) subunits are tandemly organized on chromosome 4q22 as a gene cluster. The alpha form of ADH is monomorphic and is predominantly expressed in fetal and infant livers. ADH activity decreases during gestation and demonstrates limited expression during adulthood, however, the genes encoding beta and gamma subunits are polymorphic and strongly expressed in adult livers. The physiologic function for ADH in the liver is the removal of ethanol in the intestinal tract.