c-Fos Background Information The c-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phospho-protein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. Functional homologs of c-Fos include the Fra-1, Fra-2 and Fos B genes. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites.
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c-Fos (D-1)
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c-Fos (D-1): sc-8047. Western blot analysis of c-Fos expression in NIH/3T3 nuclear extract (A) and from PMA-treated NIH/3T3 nuclear extract (B).
c-Fos (D-1): sc-8047. Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing nuclear staining of glandular cells.
