Cdc34B Background Information The eukaryotic cell division cycle consists of a number of gene-controlled sequences that involve cyclin dependent kinases (Cdks) and cell division control (Cdc) proteins. Cdc34B, also known as UBE2R2 (Ubiquitin-conjugating enzyme E2 R2) or UBC3B, is a 238 amino acid member of the E2 ubiquitin-conjugating enzyme family. Similar to Cdc34, Cdc34B functions to catalytically attach ubiquitin to various proteins, such as ∫-TrCP (an F-box protein that mediates ∫-catenin degradation), via an ATP-dependent reaction that yields AMP, a diphosphate and a ubiquitin-tagged protein. Cdc34B can be phosphorylated by the protein kinase CK2 (Casein kinase II), thereby allowing Cdc34B to regulate ∫-TrCP substrate recognition and, ultimately, enhance ∫-catenin degradation. Due to its ability to control ∫-TrCP activity, Cdc34B is thought to play a key role in cell cycle progression.
Cdc34B (L12)
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Cdc34B (L12): sc-81828. Western blot analysis of Cdc34B expression in Jurkat whole cell lysate.
