L3MBTL2 (E-16) Antibody (항체): sc-86512

L3MBTL2 Background Information
Polycomb group (PcG) proteins are important for maintaining the transcriptionally repressed state of target genes and are thought to function via chromatin modification. L3MBTL2 (Lethal(3)malignant brain tumor-like 2 protein), also known as L3MBT or H-l(3)mbt-l, is a 705 amino acid member of the PcG family. Localized to the nucleus, L3MBTL2 associates with chromatin-remodeling complexes and helps inhibit the expression of proteins that trigger the cell to enter mitosis. During the G0 phase of the cell cycle, L3MBTL2 is part of a complex that contains other proteins (such as HP1©, E2F-6 and Max) that participate in transcriptional repression. L3MBTL2 contains one FCS-type zinc finger and four MBT repeats and is expressed as three isoforms due to alternative splicing events.