epitope mapping at the N-terminus of RoXaN of human origin
recommended for detection of RoXaN of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine and bovine
TransCruz reagent for Gel Supershift and ChIP applications, sc-86839 X, 100 µg/0.1 ml
RoXaN Background Information RoXaN (zinc finger CCCH-type containing 7B), is a 993 amino acid protein likely involved in translational regulation whose alternative names include rotavirus 'X'-associated non-structural protein, ubiquitous tetratricopeptide containing protein RoXaN, ZC3H7B, FLJ13787, KIAA1031, or DKFZp434K0920. RoXaN localizes to the nucleus and has been identified as a novel cellular protein-binding partner for the rotavirus nonstructural protein NSP3, which is involved in rotavirus replication. RoXaN’s nuclear localization is known to appear disguised upon infection with rotavirus A. Two RoXaN isoforms exist as a result of alternative splicing, and RoXaN also contains one C2H2-type zinc finger, three TPR repeats and four C3H1-type zinc fingers. RoXaN contains one paxillin leucine-aspartate repeat (LD) motif in addition to a coiled-coil region which assist in protein-protein interactions. The gene encoding RoXaN maps to human chromosome 22q13.1.
