epitope mapping within an internal region of ZDHHC8 of human origin
recommended for detection of ZDHHC8 of mouse, rat and human origin by WB, IF and ELISA; non cross-reactive with other ZDHHC family members; also reactive with additional species, including equine, canine and porcine
TransCruz reagent for Gel Supershift and ChIP applications, sc-86945 X, 200 µg/0.1 ml
ZDHHC8 Background Information Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZDHHC8 (zinc finger, DHHC-type containing 8), also known as KIAA1292, ZDHHCL1 or ZNF378 (zinc finger protein 378), is a 765 amino acid multi-pass membrane protein that localizes to the membrane of cytoplasmic vesicles and contains one DHHC-type zinc finger. Expressed as multiple alternatively spliced isoforms, ZDHHC8 functions as a putative palmitoyltransferase that catalyzes the conversion of palmitoyl-CoA and a protein-cysteine to an S-palmitoyl protein and free CoA, a reaction that is important in glutamatergic transmission. Defects in the gene encoding ZDHHC8 may be associated with an increased susceptibility to schizophrenia.
