epitope mapping near the N-terminus of Six1 of human origin
recommended for detection of Six1, Six2 and Six4 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
blocking peptide, sc-9708 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-9708 X, 200 µg/0.1 ml
Six1/2/4 Background Information Originally identified as homologues of the Drosophila sine oculis (so) genes, the SIX gene family encodes transcription factors that are characterized by a conserved DNA-binding homeodomain and an upstream SIX domain. The Six family proteins may have a role in vertebrate development and also in the maintenance of tissue differentiation. The human SIX1 gene maps to chromosome 12q23 and is expressed as a nuclear phosphoprotein in adult skeletal muscle. The Six1 protein over-expressed in many primary mammary carcinomas and in most metastatic lesions and in the posterior limb regions of the mouse embryo during development. Six1 and Six4 have a role in controlling muscle formation by binding the DNA motif MEF3 and activation of the regulatory protein, myogenin. The human Six4 protein maps to chromosome 14q23 and encodes a 781 amino acid protein. Six4 is expressed in the mantle layer of the developing brain and spinal cord in mouse. The human Six2 protein is expressed in skeletal muscle, pancreas, ovary and sclera and is encoded by a gene mapping to chromosome 2p16-p15.
Six1/2/4 (N-19)
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Six1/2/4 (N-19): sc-9708. Western blot analysis of Six1/2/4 expression in NIH/3T3 whole cell lysate.
