epitope corresponding to amino acids 1-96 representing full length LSm8 of human origin
recommended for detection of LSm8 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
TransCruz reagent for Gel Supershift and ChIP applications, sc-98327 X, 200 µg/0.1 ml
LSm8 Background Information Sm and Sm-like (LSm) proteins form donut-shaped heptameric complexes that are involved in various steps of RNA metabolism. LSm proteins are ubiquitously expressed and facilitate RNA-protein interactions and structural changes that are required during ribosomal subunit assembly. LSm8, also known as YJR022W, is a member of the snRNP Sm proteins family. It is a component of the LSm2-8 complex which plays a role in the processing of pre-snoRNAs, pre-tRNAs and pre-rRNAs, as well as the turnover of pre-mRNAs. The LSm2-8 complex is also essential for the nuclear localization of the U6 snRNA. LSm8 localizes to the nucleus and specifically binds the U6 snRNA 3’-terminal U-tract.
